Synlett 2007(14): 2197-2200  
DOI: 10.1055/s-2007-984913
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© Georg Thieme Verlag Stuttgart · New York

Heteropoly Acids Catalyzed Direct Mannich Reactions: Three-Component Synthesis of N-Protected β-Amino Ketones

Rui Wang, Taikun Huang, Lin Shi, Bogang Li, Xiaoxia Lu*
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P. R. of China
Fax: +86(28)85222753; e-Mail: luxx@cib.ac.cn;
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Publication History

Received 10 May 2007
Publication Date:
20 July 2007 (online)

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Abstract

Heteropoly acids efficiently catalyzed one-pot three-component Mannich reactions of aryl aldehydes, aryl ketones, and carbamates at ambient temperature and afforded the corresponding N-protected β-amino ketones in good to excellent yields. This method provides a novel and improved modification of three-component Mannich reactions in terms of a wide scope of aldehydes, ketones and carbamates, economic viability and reusability.

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