Synlett 2007(12): 1877-1880  
DOI: 10.1055/s-2007-984522
LETTER
© Georg Thieme Verlag Stuttgart · New York

The α-Alkylation of Methyl Ketones with Primary Alcohols Promoted by Nickel Nanoparticles under Mild and Ligandless Conditions

Francisco Alonso*, Paola Riente, Miguel Yus*
Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Química Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain
Fax: +34(96)5903549; e-Mail: falonso@ua.es; e-Mail: yus@ua.es;
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Publikationsverlauf

Received 25 April 2007
Publikationsdatum:
25. Juni 2007 (online)

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Abstract

Nickel nanoparticles have been found to promote the α-alkylation of ketones with primary alcohols in the absence of any added ligand or base, under mild reaction conditions.