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Synthesis 2007(18): 2823-2828  
DOI: 10.1055/s-2007-983878
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis and Antiviral Evaluation of Sugar Uracil-1-ylmethylhydrazones and Their Oxadiazoline Derivatives

Omar M. Ali*, Hamada H. Amer, Adel A.-H. Abdel-Rahman*
Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt
Fax: +20(48)2235689; e-Mail: adelnassar63@hotmail.com; e-Mail: omasaf@hotmail.com;
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Publication History

Received 12 March 2007
Publication Date:
29 August 2007 (online)

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Abstract

1-Carbethoxymethyluracils have been synthesized and derivatized to the corresponding hydrazides, which were reacted with monosaccharides to afford the corresponding sugar hydrazones. Acetylation of the latter with acetic anhydride in pyridine, afforded the per-O-acetyl derivatives, while heating in acetic anhydride gave the corresponding oxadiazolines. The prepared compounds were tested for antiviral activity against hepatitis B virus and showed moderate activities.

Key words

antiviral agents - carbohydrates - hydrazones - nucleobases - nucleosides

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