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Synfacts 2007(10): 1071-1071  
DOI: 10.1055/s-2007-983858
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Rhodium-Catalyzed [2+2+2] Cycloadditions by Directed C-H Activation

Contributor(s): Mark Lautens, Michael Langer
K. Tsuchikama, Y. Kuwata, Y.-k. Tahara, Y. Yoshinami, T. Shibata*
Waseda University, Tokyo, Japan
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Publication History

Publication Date:
07 November 2007 (online)

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Significance

The direct functionalization of C-H bonds by transition metals like palladium or rhodium has been a central research topic in the last years. The cyclization of enynes and diynes with appropriate reaction partners yields complex molecules in a single step. The authors report a rhodium-catalyzed cyclization of diynes 1 and enynes 2 with ortho-CH activated aromatic ketones to yield the corresponding products in high E/Z selectivity or enantioselectivity.