Horm Metab Res 2007; 39(7): 534-537
DOI: 10.1055/s-2007-982529
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

ACE Gene Polymorphism in Peripheral Vascular Disease[*]

Y. Başar 1 , N. Salmayenli 2 , M. Aksoy 1 , Ş. Seçkin 3 , M. Aydın 4 , E. Özkök 4
  • 1Department of General Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
  • 2Department of Clinical Biochemistry, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
  • 3Department of Biochemistry, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
  • 4Department of Neuroscience, Istanbul University, Institute of Experimental Medicine Research
Further Information

Publication History

received 8.6.2006

accepted after second revision 16.1.2007

Publication Date:
05 July 2007 (online)

Abstract

Peripheral vascular disease is an atherosclerotic process. It has been suggested that angiotensin converting enzyme insertion/deletion polymorphism is associated with atherosclerosis. The aim of this study was to investigate the role of the insertion/deletion polymorphism of the angiotensin-converting enzyme in Turkish patients with peripheral vascular disease in Western part of Turkey. We also investigated the relationship between serum angiotensin converting enzyme activity and distribution of genotypes in both patients and control group. The study group consisted of 78 patients with peripheral vascular disease. The control group consisted of 73 healthy adults. Serum angiotensin converting enzyme activities in patients were higher than those of the control group (p<0.05). Angiotensin converting enzyme genotype frequencies in patients were observed as 28.2%, 18% and 53.8% for DD, II and ID polymorphism, respectively. These frequencies in controls were 42.5%, 20.5% and 37% for DD, II and ID, respectively. Serum angiotensin converting enzyme activities in both groups with II genotype were significantly lower than those with ID and DD genotype (p<0.05). Although conflicting results have been reported about this polymorphism in patients with peripheral vascular disease, we suggest that the angiotensin converting enzyme ID genotype may be a risk factor for peripheral vascular disease.

1 The paper has already been presented at the 16th IFCCFESCC European Congress of Clinical Chemistry and Laboratory Medicine, Glasgow 2005.

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1 The paper has already been presented at the 16th IFCCFESCC European Congress of Clinical Chemistry and Laboratory Medicine, Glasgow 2005.

Correspondence

Prof. Dr. N. Salmayenli

Department of Clinical Biochemistry

Istanbul University

Istanbul Faculty of Medicine

34390 Istanbul

Turkey

Phone: +90/212/414 20 00 31372

Email: salmayenlin@istanbul.edu.tr