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Horm Metab Res 1995; 27(9): 415-418
DOI: 10.1055/s-2007-979990
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© Georg Thieme Verlag Stuttgart · New York

Endogenous Nitric Oxide is Not Involved in Acute Parathyroid Hormone-Induced Hypotension in Rat: Effect of Hypertension and Hypoparathyroid Status

R. Schleiffer*, Fanny Pernot, A. Gairard
  • Pharmacologie et Physiopathologie Cellulaires, CNRS URA 600, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg, France
* IRCAD, Hôpitaux Universitaires, Strasbourg, France
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Publication History

1994

1995

Publication Date:
23 April 2007 (online)

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Abstract

The present study investigated the acute hypotensive effed of parathyroid hormone (PTH) in anesthetized adult spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats. Furthermore, in order to determine the possible contribution of nitric oxide (NO), a mediator of endothelium-dependent vasorelaxation, hypotensive responses to PTH were obtained in the presence of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthesis. The hypotensive effect of PTH (expressed as % of baseline blood pressure) was similar for the two strains. In the presence of 1-NAME (18.5 µmol/kg), both strains demonstrated a similar hypotensive response to PTH, indicating that the hypotensive response to PTH is NO-independent.

Key words

Nitric Oxide - Parathyroid Hormone - Spontaneously Hypertensive Rats - Hypotension - NG-Nitro-L-Arginine Methyl Ester