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Horm Metab Res 1995; 27(8): 372-375
DOI: 10.1055/s-2007-979981
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© Georg Thieme Verlag Stuttgart · New York

Physiological Effect of Glucagon in Human Isolated Adipocytes

Almudena Perea1 , F. Clemente1 , J. Martinell2 , María L. Villanueva-Peñacarrillo1 , Isabel Valverde1
  • 1Department of Metabolism, Nutrition and Hormones, and of Fundación Jiménez Díaz, Madrid, Spain
  • 2Cardiovascular Surgery, Fundación Jiménez Díaz, Madrid, Spain
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Publication History

1995

1995

Publication Date:
23 April 2007 (online)

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Abstract

In human isolated adipocytes, glucagon induces a dose dependent increment of the glycerol release, which is already observed at physiological concentrations of the hormone. Furthermore, glucagon at 10-8 M, significantly stimulates the adenylate cyclase activity in both non-solubilized and solubilized fat plasma membranes, and at already 10-11 M, a significant increment of the adipocyte cAMP content is observed. These data support previous in vivo positive results indicating that glucagon plays a role in human fat metabolism.

Key words

Human Adipocytes - Glucagon - Lipolysis - cAMP