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Horm Metab Res 1995; 27(4): 204-207
DOI: 10.1055/s-2007-979941
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© Georg Thieme Verlag Stuttgart · New York

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H. Honjo2 , K. Tanaka2 , T. Kashiwagi2 , M. Urabe2 , H. Okada2 , M. Hayashi1 , K. Hayashi1
  • 1Heijo-en, Nara, Japan
  • 2Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto
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Publication History

1994

1994

Publication Date:
23 April 2007 (online)

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Abstract

Some reports have suggested the ameliorative effects of estrogens on clinical symptoms, such as short memory, in women suffering from senile dementia-Alzheimer's tpye, in vivo. The action mechanism of estrogen remains to be clarified, but 1) an anti-depressive effect, 2) improvement of cerebral blood flow, 3) direct stimulation of neuron, 4) development of gliacyte and 5) suppression of apolipoprotein E have been suggested. Some mechanisms may be combined, contributing to the beneficial effects on clinical symptoms.

Key words

Senile Dementia-Alzheimer's Type - Estrogen - Depressive Status - Cerebral Blood Flow - Neuron - Apolipoprotein E