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Horm Metab Res 1997; 29(9): 427-429
DOI: 10.1055/s-2007-979070
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© Georg Thieme Verlag Stuttgart · New York

Effects of Gamma-Butyric Acid on the Release of Thyrotropin-releasing Hormone from the Rat Retina in vitro

T. Mitsuma1 , N. Rhue1 , M. Kayama1 , Y. Yokoi1 , M. Izumi1 , K. Adachi1 , T. Wago1 , Y. Hirooka1 , T. Nogimori2
  • 1Fourth Department of Internal Medicine and Laboratory Medicine, Aichi Medical University, Nagakute, Aichi, Japan
  • 2Department of Internal Medicine, Konanshowa Hospital Konan, Aichi, Japan
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Publication History

1996

1997

Publication Date:
23 April 2007 (online)

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Effects of gamma-butyric acid (GABA) on the release of thyrotropin-releasing hormone (TRH) from the rat retina in vitro were studied. The rat retina was incubated in medium 199 (pH 7.4) with 1.0 mg/ml of bacitracin and 100 µg/ml of ascorbic acid (medium). The amount of TRH release into the medium was measured by radioimmunoassay. The TRH release from the rat retina was inhibited significantly in a dose-related manner with the addition of GABA, but not with bicuculline. The inhibitory effect of GABA on TRH release from the retina was blocked by adding bicuculline to the medium. The findings suggest that the GABAergic system inhibits TRH release from the rat retina in vitro.

Key words

Thyrotropin-releasing hormone - GABA - Retina

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