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Horm Metab Res 1998; 30(5): 241-243
DOI: 10.1055/s-2007-978874
Originals Experimental

© Georg Thieme Verlag Stuttgart · New York

Vasoactive Intestinal Peptide Stimulates Rat Adrenal Glucocorticoid Secretion, Through an ACTH Receptor-Dependent Activation of the Adenylate Cyclase Signaling Pathway

G. Mazzocchi, P. Rebuffat, L. Gottardo, G. G. Nussdorfer
  • Department of Anatomy, University of Padua, Padua, Italy
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Publication History

1997

1998

Publication Date:
20 April 2007 (online)

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Vasoactive intestinal peptide (VIP) concentration-dependently enhanced corticosterone and cyclic-AMP release by dispersed rat inner adrenocortical cells. A VIP-receptor antagonist and the ACTH-receptor antagonist corticotropin-inhibiting peptide annulled both adrenocortical-cell responses to VIP, while the protein kinase (PKA) inhibitor H-89 blocked only corticosterone response. Collectively, these findings suggest that VIP stimulates glucocorticoid secretion of rat adrenals, through the aspecific activation of ACTH receptors coupled with the adenylate cyclase/PKA-dependent signaling pathway.

Key words

VIP - Glucocorticoid Secretion - ACTH Receptor - Adenylate Cyclase-Dependent Cascade