Insulin Resistance, Dehydroepiandrosterone Sulfate and Sex Hormone-Binding Globulin in Essential Hypertension*

J. Serrano-Gotarredona; H. F. Escobar-Morreale; J. M. Sancho; R. García-Robles

doi:10.1055/s-2007-978856

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1998; 30(3): 153-157
DOI: 10.1055/s-2007-978856

Originals Clinical

Insulin Resistance, Dehydroepiandrosterone Sulfate and Sex Hormone-Binding Globulin in Essential Hypertension*

J. Serrano-Gotarredona¹ , H. F. Escobar-Morreale² , J. M. Sancho² , R. García-Robles²

¹Department of Endocrinology. Hospital General Universitario de Alicante, Spain
²Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain

* Presented in part at the 7th European Meeting on Hypertension, Milán, Italy, June 1995

Abstract

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Objective: To evaluate insulin sensitivity, and serum levels of sex hormone-binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEA-sulfate), in patients with essential hypertension. Design and methods: In 15 non-treated hypertensive patients, insulin resistance was measured by an insulin suppression test (IST). Serum levels of DHEA-sulfate and SHBG were measured at the beginning and at the end of the IST. The results were compared to those of a control group of 10 healthy normotensive subjects matched for age, sex and body mass index (BMI).

Key words

Hypertension - Insulin - Insulin Resistance - Dehydroepiandrosterone Sulfate - Sex Hormone-Binding Globulin

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