Partial Seizures Associated with Antiphospholipid Antibodies in Childhood

Lucia Angelini; T. Granata; F. Zibordi; S. Binelli; C. Zorzi; C. Besana

doi:10.1055/s-2007-973570

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Neuropediatrics 1998; 29(5): 249-254
DOI: 10.1055/s-2007-973570

Original articles

Partial Seizures Associated with Antiphospholipid Antibodies in Childhood

Lucia Angelini¹ , T. Granata¹ , F. Zibordi¹ , S. Binelli² , C. Zorzi¹ , C. Besana³

¹Departments of Neuropediatrics National Neurological Institute "C. Besta", Milano, Italy,
²Departments of Neurophysiology, National Neurological Institute "C. Besta", Milano, Italy,
³2nd Department of Internal Medicine, University of Milano, IRCCS San Raffaele, Milano, Italy

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Publication History

Publication Date:
12 March 2007 (online)

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Abstract

We report antiphospholipid antibody positivity in three of a consecutive series of 23 children presenting partial epileptic seizures. There was no clinical or serological evidence of systemic lupus erythematosus or other connective-tissue disease.

Neither computed tomography nor magnetic resonance imaging revealed ischemic alteration. The presence of antiphospholipid antibodies in 3/23 children may indicate that immune-mediated neuronal damage could be a pathogenetic mechanism for partial epilepsy.

Key words

Antiphospholipid antibodies - Partial seizures -Childhood