Exp Clin Endocrinol Diabetes 2007; 115 - P01_056
DOI: 10.1055/s-2007-972312

Impact of resistin on the incidence of vascular events in patients undergoing coronary angiography

G Höfle 1, CH Saely 2, L Risch 3, L Koch 3, F Schmid 3, S Aczél 2, S Berchtold 4, T Marte 2, H Drexel 2
  • 1LKH Feldkirch und LKH Hohenems, Innere Medizin, Hohenems, Austria
  • 2LKH Feldkirch, Innere Medizin, Feldkirch, Austria
  • 3LKH Feldkirch, Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria
  • 4LMZ laboratories, Schaan, Liechtenstein

Objective: The adipose tissue-related hormone resistin is predominantly secreted by inflammatory cells. We assessed the impact of circulating resistin on the prevalence of significant coronary artery stenoses and on the incidence of vascular events.

Methods: We performed a cross-sectional and prospective study in 547 patients (376 men, 171 women) with suspected or established coronary artery disease. We studied serum resistin, insulin resistance, lipids, high-sensitivity C-reactive protein (hsCRP) and coronary angiograms. Coronary artery stenoses with a lumen narrowing of ≥50% were regarded significant. We also recorded vascular events over a follow-up of 4.0±0.7 years.

Results: Serum resistin correlated significantly with hsCRP (rs=0.228; p<0.001). From our patients, 330 (60%) had significant coronary artery stenoses. Serum resistin was not significantly different in patients with significant coronary artery stenoses compared with patients without coronary artery stenoses (4.8±2.4 vs. 4.7±2.9 ng/ml; p=0.265). Multivariate logistic regression analysis adjusting for conventional vascular risk factors (age, gender, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, hsCRP, glomerular filtration rate, body mass index, type 2 diabetes, hypertension and smoking) showed no significant association of serum resistin with the presence of significant coronary artery stenoses (standardized adjusted odds ratio of 0.927, 95% confidence interval (CI) 0.741–1.161; p=0.510). Furthermore, after multivariate adjustment Cox regression exhibited no significant association of serum resistin with vascular events (hazard ratio 0.936, 95% CI 0.753–1.162; p=0.549).

Conclusions: Serum resistin is neither associated with the presence of significant coronary artery stenoses nor with vascular events in patients undergoing coronary angiography.