Subscribe to RSS
DOI: 10.1055/s-2007-969633
© Georg Thieme Verlag Stuttgart · New York
Studies on Cryptolepine
III: Effect of Cryptolepine on the Tone and Prostaglandin Production in Isolated Rabbit DuodenumPublication History
Publication Date:
26 February 2007 (online)
Abstract
The inhibitory effects of cryptolepine and its interaction with prostaglandin E2, indomethacin, adrenaline and acetylcholine have been investigated on the isolated rabbit duodenum.
Cryptolepine (10-20 µg ml-1) or adrenaline (0.5-1 µg ml-1) or indomethacin (10-20 µg ml-1) abolished or reduced pendular contractions and relaxed the tissue. Cryptolepine (20 µg ml-1) produced an initial contraction before relaxation of the tissue.
Cryptolepine (10-20 µg ml-1) abolished responses of the duodenum to added prostaglandin E2 and acetylcholine, but failed to reduce prostaglandin production.
The results suggested that cryptolepine antagonises prostaglandin, but has no inhibitory effect on its synthesis or release.