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Planta Med 1985; 51(6): 515-517
DOI: 10.1055/s-2007-969579
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© Georg Thieme Verlag Stuttgart · New York

Study of Caffein - Catechin Association in Lyophilized Fresh Seeds and in Stabilized Extract of Cola nitida

C. Maillard1 , A. Babadjamian2 , G. Balansard1 , B. Ollivier1 , D. Bamba3
  • 1Laboratoire de Pharmacognosie, Faculté de Pharmacie 27, Boulevard J. Moulin, 13385 Marseille Cedex 5, France
  • 2Institut de Pétroléochimie et de Synthèse Organique Industrielle, Faculté des Sciences et Techniques, St. Jérome, rue H. Poincaré, 13397 Marseille Cedex 13, France
  • 3Laboratoire de Pharmacognosie, Ecole de Pharmacie, 01 B. P. V 34 Abidjan, Côte d'Ivoire
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1985

1985

Publication Date:
26 February 2007 (online)

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Abstract

Caffein-catechin association has been demonstrated in lyophilized fresh seeds and in stabilized extract of Cola nitida (Vent.) A. Chev. by using various analytical techniques which have made it possible to determine specifically the concentrations of free caffein versus associated caffein. Associated caffein varies from 0% in dried seeds to 91% in lyophilized fresh seeds and in stabilized extract of Cola. It was possible to simulate these quantitative variations of associated caffein by using an experimental model with a saturated aqueous solution of caffein and various amounts of catechin. Infrared spectrophotometric studies have shown the hydrogen bond type of the association. The differences of pharmacological effects of fresh and dried seeds may be due to the varying concentrations of associated and free caffein.