Studies on the Taiwan Folk Medicine; III. A Smooth Muscle Relaxant from Onychium siliculosum, Onitin

Shien-Tsong Ho; Meei-Shieu Yang; Tian-Shung Wu; Chao-Hsiung Wang

doi:10.1055/s-2007-969431

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Planta Med 1985; 51(2): 148-150
DOI: 10.1055/s-2007-969431

Research Articles

Studies on the Taiwan Folk Medicine; III. A Smooth Muscle Relaxant from Onychium siliculosum, Onitin

Shien-Tsong Ho¹ , Meei-Shieu Yang² , Tian-Shung Wu³ , Chao-Hsiung Wang³

¹Department of Biology, Chia Nan Junior College of Pharmacy, Jen-Te Hsiang, Tainan, Taiwan 717, R.O.C.
²Department of Pharmacology, Chia Nan Junior College of Pharmacy, Jen-Te Hsiang, Tainan, Taiwan 717, R.O.C.
³Department of Chemistry, Chia Nan Junior College of Pharmacy, Jen-Te Hsiang, Tainan, Taiwan 717, R.O.C.

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Publication History

1984

1984

Publication Date:
26 February 2007 (online)

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Abstract

The pharmacological properties of onitin, onitinoside and onitisin, three phenolic pterosins, isolated from Onychium siliculosum have been investigated. Their predominant effects are to inhibit the contraction of isolated guinea-pig ileum. In these three compounds, onitin is the most potent one. Onitin (1 × 10^-4M) inhibits both the D receptor and M receptor of 5-HT. The antagonism of onitin against histamine is non-competitive.