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Synfacts 2007(10): 1017-1017
DOI: 10.1055/s-2007-968951
DOI: 10.1055/s-2007-968951
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (S,S)-Reboxetine Succinate
K. E. Henegar*, M. Cebula
Pfizer Global Research and Development, Ann Arbor, USA
Further Information
Publication History
Publication Date:
07 November 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200710/lookinside/thumbnails/10.1055-s-2007-968951-1.jpg)
Significance
Reboxetine mesylate is a selective norepinephrine uptake inhibitor currently marketed as the racemate for the treatment of depression. (S,S)-Reboxetine succinate is in development for the treatment of neuropathic pain. The asymmetric synthesis depicted is based on the Sharpless asymmetric epoxidation of cinnamyl alcohol (er = 96:4).