Nickel-Catalyzed Intermolecular Reductive Coupling of Enones and Alkynes

A. Herath; B. B. Thompson; J. Montgomery

doi:10.1055/s-2007-968937

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Synfacts 2007(10): 1092-1092
DOI: 10.1055/s-2007-968937

Metal-Mediated Synthesis

Nickel-Catalyzed Intermolecular Reductive Coupling of Enones and Alkynes

Contributor(s): Paul Knochel, Tobias Thaler
A. Herath, B. B. Thompson, J. Montgomery*
University of Michigan, Ann Arbor, USA

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Publikationsverlauf

Publikationsdatum:
07. November 2007 (online)

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Significance

A Ni-catalyzed intermolecular coupling of enones with alkynes is reported. In contrast to their aldehyde counterparts no ring closure is observed. Couplings with aromatic alkynes or ynoates proceed with high regioselectivities, whereas nonaromatic internal alkynes deliver product mixtures.