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Synfacts 2007(9): 0967-0967  
DOI: 10.1055/s-2007-968867
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Alkylative Aldol Reaction: Multicomponent Assembly of δ-Lactones

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
K. Oisaki, D. Zhao, M. Kanai, M. Shibasaki*
The University of Tokyo, Japan
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Publication History

Publication Date:
23 August 2007 (online)

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Significance

This paper is a significant contribution to the emerging field of multicomponent reactions. Three distinct bond-forming events take place in a single step to give δ-lactones containing an asymmetric quaternary carbon stereocenter. The asymmetric aldol reaction to ketones is the key enantioselective step in this protocol.