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Synfacts 2007(8): 0836-0836
DOI: 10.1055/s-2007-968774
DOI: 10.1055/s-2007-968774
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Cyclopropanation: Silver-Catalyzed Reactions of Aryldiazoacetates
J. L. Thompson, H. M. L. Davies*
The State University of New York, Buffalo, USA
Further Information
Publication History
Publication Date:
24 July 2007 (online)
Significance
The Davies group describes the highly chemoselective cyclopropanation of mono- and disubstituted alkenes with aryldiazoacetates catalyzed by AgSbF6. This system offers distinct advantages over the commonly employed dirhodium systems typically used. Chemoselectivity for cyclopropanation over C-H insertion is greatly favored with silver while rhodium is highly chemoselective for the latter.