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Synfacts 2007(8): 0789-0789
DOI: 10.1055/s-2007-968710
DOI: 10.1055/s-2007-968710
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (-)-Belactosin C
S. W. Cho, D. Romo*
Texas A&M University, college Station, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
24. Juli 2007 (online)
Significance
Isolated from the fermentation broth of streptomyces sp. UCK14, (-)-belactosin C displays anticancer activitiy by inhibiting the 20S proteasome. The synthesis depicted above features a distal double diastereoselective and proximal double diastereoselective tandem Mukaiyama aldol-lactonization (TMAL) process to obtain cis- and trans-β-lactones in a single step.