RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2007(6): 0604-0604
DOI: 10.1055/s-2007-968560
DOI: 10.1055/s-2007-968560
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Stereoselective Synthesis of Tri- and Tetrasubstituted Alkenes from Alkynes
K. Murakami, H. Ohmiya, H. Yorimitsu*, K. Oshima*
Kyoto University, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Mai 2007 (online)
Significance
This report presents a new catalytic system to achieve the carbometallation of unfunctionalized alkynes 1. Chromium salts promoted the arylmagnesiation of alkynes in the presence of pivalic acid to obtain the corresponding alkenes 3 with very high stereoselectivity. After the aryl addition, the carbometallated species can be trapped with various electrophiles to lead to tetrasubstituted alkenes 4-8.