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Synfacts 2007(6): 0633-0633
DOI: 10.1055/s-2007-968538
DOI: 10.1055/s-2007-968538
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Low-Temperature Cross-Coupling of Functionalized Grignard Reagents
R. Martin, S. L. Buchwald*
Massachusetts Institute of Technology, Cabridge, USA
Further Information
Publication History
Publication Date:
22 May 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200706/lookinside/thumbnails/10.1055-s-2007-968538-1.jpg)
Significance
The Kumada-Corriu cross-coupling process is very attractive since the required (het)arylmagnesium species, including polyfunctionalized ones, can be readily prepared directly by the halogen-magnesium exchange or a metallation reaction. The group of Buchwald report herein a robust protocol, allowing a very efficient coupling of polyfunctionalized arylmagnesium species at the temperatures, which tolerate a vast majority of functional groups. This method is therefore extremely attractive for the direct synthesis of functionalized biaryls starting from (het)aryl halides.