Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2007(6): 0642-0642
DOI: 10.1055/s-2007-968535
DOI: 10.1055/s-2007-968535
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Substituted Pyrroles via Cu-Catalyzed Vinylation of Hydrazides
M. Rodríguez Rivero, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
Further Information
Publication History
Publication Date:
22 May 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200706/lookinside/thumbnails/10.1055-s-2007-968535-1.jpg)
Significance
Pyrroles are found in many naturally occurring molecules. They are also widely used in modern material science. The authors developed a new convenient synthesis of polysubstituted pyrroles, consisting of a novel Cu-catalyzed bis-vinylation of Boc-hydrazines followed by the Piloty-Robinson rearrangement-cyclization of ketazines. It allows a flexible and regioselective preparation of a variety of functionalized pyrroles from simple and readily available precursors.