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Synfacts 2007(6): 0567-0567
DOI: 10.1055/s-2007-968520
DOI: 10.1055/s-2007-968520
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Tamiflu
T. Mita, N. Fukuda, F. X. Roca, M. Kanai*, M. Shibasaki*
The University of Tokyo, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Mai 2007 (online)
Significance
Tamiflu is a potent neuramidase inhibitor which is used for the treatment of the avian H5N1 virus. Key steps in the 15-step asymmetric synthesis depicted are (a) a catalytic asymmetric cleavage of meso-aziridine A with TMSN3 and (b) a diastereoselective cyanophosphorylation of the enone E.