Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2007(6): 0570-0570
DOI: 10.1055/s-2007-968518
DOI: 10.1055/s-2007-968518
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of RK-397
M. J. Mitton-Fry, A. J. Cullen, T. Sammakia*
University of Colorado, Boulder, USA
Further Information
Publication History
Publication Date:
22 May 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200706/lookinside/thumbnails/10.1055-s-2007-968518-1.jpg)
Significance
RK-397 possesses antifungal, antitumor and antibacterial activity. Stereoselective aldol reactions, hydroxyl-directed reductions and allylborations were used to create most of the stereocenters in the polyol portion of the target. Markworthy features include the cross-metathesis of heptatrienal and fragment A to initiate construction of the polyene fragment and the 1,5-asymmetric induction used to fashion fragment D.