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Synfacts 2007(6): 0574-0574  
DOI: 10.1055/s-2007-968516
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Paroxetine and (+)-Laccarin

Contributor(s): Philip Kocienski
J. F. Bower, T. Riis-Johannessen, P. Szeto, A. J. Whitehead, T. Gallagher*
Bristol University, UK
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Publikationsverlauf

Publikationsdatum:
22. Mai 2007 (online)

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Significance

A new synthesis of scalemic piperidines featuring the nucleophilic substitution of six-membered 1,3-sulfamidates was employed in syntheses of the antidepressant paroxetine and the phosphodiesterase inhibitor laccarin.