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Synfacts 2007(4): 0398-0398
DOI: 10.1055/s-2007-968384
DOI: 10.1055/s-2007-968384
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Chiral Bisimidazoline Ligands for Highly Enantioselective Henry Reaction
K. Ma, J. You*
Sichuan University, Chengdu, P. R. of China
Further Information
Publication History
Publication Date:
23 March 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200704/lookinside/thumbnails/10.1055-s-2007-968384-1.jpg)
Significance
In this paper, the authors developed a new synthesis of Beller’s bisimidazoline ligand (Org. Lett. 2005, 7, 3393-3396) that allows modified versions to be readily prepared. They tested several of these ligands in a copper-catalyzed enantioselective nitroaldol reaction and found an N-phenyl bisimidazoline that was particularly effective.