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Synfacts 2007(4): 0402-0402  
DOI: 10.1055/s-2007-968381
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Niobium-Catalyzed Enantioselective Desymmetrization of meso-Epoxides

Contributor(s): Mark Lautens, Yann Béthuel
K. Arai, M. M. Salter, Y. Yamashita, S. Kobayashi*
The University of Tokyo, Japan
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Publikationsdatum:
23. März 2007 (online)

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Significance

In the present paper, the authors follow up on their recent work using niobium and a BINOL derivative to achieve asymmetric Mannich-type reactions (Angew. Chem. Int. Ed. 2005, 44, 761-764). They report on the efficient desymmetrization of meso-epoxides.