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Synfacts 2007(4): 0383-0383
DOI: 10.1055/s-2007-968317
DOI: 10.1055/s-2007-968317
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York
Stepwise Synthesis of Tetrameric Purine
H. Guthmann, M. Könemann, T. Bach*
TU München and BASF AG, Ludwigshafen, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. März 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200704/lookinside/thumbnails/10.1055-s-2007-968317-1.jpg)
Significance
The authors examined the regioselectivity and reactivity of several halogenated purines in cross-coupling reactions. Employing the N-benzyl-protected purine (1) as a building block, they successfully synthesized a cyclic tetrameric purine-palladium complex (8), via repetitive transmetallation, iodo-de-chlorination and cross-coupling reactions. This stepwise synthetic route afforded 8 in eight steps and 17% overall yield.