Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2007(4): 0348-0348
DOI: 10.1055/s-2007-968291
DOI: 10.1055/s-2007-968291
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Plakortone B
M. F. Semmelhack*, R. J. Hooley, C. M. Kraml
Princeton University and Wyeth Research, Princeton, USA
Further Information
Publication History
Publication Date:
23 March 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200704/lookinside/thumbnails/10.1055-s-2007-968291-1.jpg)
Significance
The plakortones, isolated from Plakortis halichondrioides and Plakortis simplex, stimulate the cardiac sacroplasmic reticulum Ca2+ ATPase. The focal points of this synthesis are (1) coupling of boron-ate H and vinyl iodide F by a modified Suzuki reaction, and (2) formation of the furanolactone core by intramolecular alkoxypalladation-lactonization.