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Synfacts 2007(4): 0351-0351
DOI: 10.1055/s-2007-968283
DOI: 10.1055/s-2007-968283
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Bengazole A
J. A. Bull, E. P. Balskus, R. A. J. Horan, M. Langner, S. V. Ley*
Cambridge University, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. März 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200704/lookinside/thumbnails/10.1055-s-2007-968283-1.jpg)
Significance
Bengazole A is isolated from a Jaspis sponge. Its antifungal activity is comparable to that of amphotericin against Candida albicans and it is active against fluconazole-resistant Candida strains. The butane-2,3-diacetal protecting group (structures A and H) plays an important strategic role in the synthesis. For a previous synthesis of bengazole A, see: R. J. Mulder et al. J. Org. Chem. 1999, 64, 4995-4998.