Synlett 2007(4): 0611-0614  
DOI: 10.1055/s-2007-967976
LETTER
© Georg Thieme Verlag Stuttgart · New York

Phosphinamide-Directed ortho Metalations: Application to the Desym­metrization of the Diphenylphosphoryl Group

Ignacio Fernándeza, Pascual Oña Burgosa, Gloria Ruiz Gómeza, Caroline Bleda, Santiago García-Grandab, Fernando López Ortiz*a
a Área de Química Orgánica, Universidad de Almería, Carretera de Sacramento s/n, 04120 Almería, Spain
Fax: +34(950)015478; e-Mail: flortiz@ual.es;
b Departamento de Química Física y Analítica, Universidad de Oviedo, C/ Julián Clavería 8, 33006 Oviedo, Spain
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Received 1 November 2006
Publikationsdatum:
21. Februar 2007 (online)

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Abstract

Diphenylphosphinamides have been regioselectively ortho-lithiated under mild conditions providing a simple access to ortho-functionalized derivatives in good yields. The application of the methodology to the diastereoselective desymmetrization of the phosphorus atom is described for the first time.

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