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Synlett 2007(4): 0611-0614
DOI: 10.1055/s-2007-967976
DOI: 10.1055/s-2007-967976
LETTER
© Georg Thieme Verlag Stuttgart · New York
Phosphinamide-Directed ortho Metalations: Application to the Desymmetrization of the Diphenylphosphoryl Group
Weitere Informationen
Publikationsverlauf
Received
1 November 2006
Publikationsdatum:
21. Februar 2007 (online)


Abstract
Diphenylphosphinamides have been regioselectively ortho-lithiated under mild conditions providing a simple access to ortho-functionalized derivatives in good yields. The application of the methodology to the diastereoselective desymmetrization of the phosphorus atom is described for the first time.
Key words
phosphinamides - ortho lithiation - diastereoselectivity - organotin - directed metalation