This article is an analysis of the characteristics of exogenous endoscopy-related infections, pseudoinfections, and toxic reactions that have occurred worldwide during the period 1974 - 2004. A systematic review of the scientific literature published between 1966 and 2004 was conducted in Medline and the Food and Drug Administration Reports database, using a prospective protocol developed by the authors. The literature review identified 140 outbreaks, reported in 134 scientific articles. More than 94 % of the outbreaks identified could have been prevented by improved decontamination processes. Proper decontamination practices and the improvement of surveillance systems could reduce the clinical burden associated with exogenous endoscopy-related events.
References
-
1
Muscarella L F.
Dear Los Angeles Times: the risk of disease transmission during gastrointestinal endoscopy.
Gastroenterol Nurs.
2004;
27
271-278
-
2
Nelson D B.
Infection control during gastrointestinal endoscopy.
J Lab Clin Med.
2003;
141
159-167
-
3
Cronmiller J R, Nelson D K, Salman G. et al .
Antimicrobial efficacy of endoscopic disinfection procedures: a controlled, multifactorial investigation.
Gastrointest Endosc.
1999;
50
152-158
-
4
Foliente R L, Kovacs B J, Aprecio R M. et al .
Efficacy of high-level disinfectants for reprocessing gastrointestinal endoscopes in simulated-use testing.
Gastrointest Endosc.
2001;
53
456-462
-
5
Spach D H, Silverstein F E, Stamm W E.
Transmission of infection by gastrointestinal endoscopy and bronchoscopy.
Ann Intern Med.
1993;
118
117-128
-
6
Prakash U B.
Does the bronchoscope propagate infection?.
Chest.
1993;
104
552-559
-
7
Nelson D B.
Infectious disease complications of GI endoscopy: part I, endogenous infections.
Gastrointest Endosc.
2003;
57
546-556
-
8
Vennes J A.
Infectious complications of gastrointestinal endoscopy.
Dig Dis Sci.
1981;
26 (7 Suppl)
60S-64S
-
9
Favero M S.
Strategies for disinfection and sterilization of endoscopes: the gap between basic principles and actual practice.
Infect Control Hosp Epidemiol.
1991;
12
279-281
-
10
Axon A T.
Working Party Report to the World Congresses. Disinfection and endoscopy: summary and recommendations.
J Gastroenterol Hepatol.
1991;
6
23-24
-
11
Pajkos A, Vickery K, Cossart Y.
Is biofilm accumulation on endoscope tubing a contributor to the failure of cleaning and decontamination?.
J Hosp Infect.
2004;
58
224-229
-
12
Tunuguntla A, Sullivan M J.
Monitoring quality of flexible endoscope disinfection by microbiologic surveillance cultures.
Tenn Med.
2004;
97
453-456
-
13
Aanstoos C M.
Endoscopes: clean clear through?.
Am J Nurs.
1992;
92
14
-
14
Urayama S, Kozarek R A, Sumida S. et al .
Mycobacteria and glutaraldehyde: is high-level disinfection of endoscopes possible?.
Gastrointest Endosc.
1996;
43
451-456
-
15
Vesley D, Melson J, Stanley P.
Microbial bioburden in endoscope reprocessing and an in-use evaluation of the high-level disinfection capabilities of Cidex PA.
Gastroenterol Nurs.
1999;
22
63-68
-
16
Nelson D B.
Infectious disease complications of GI endoscopy: part II, exogenous infections.
Gastrointest Endosc.
2003;
57
695-711
-
17
Gorse G J, Messner R L.
Infection control practices in gastrointestinal endoscopy in the United States: a national survey.
Gastroenterol Nurs.
1991;
14
72-79
-
18
Seoane-Vazquez E, Rodriguez-Monguio R, Visaria J. et al .
Exogenous endoscopy-related infections, pseudo-infections, and toxic reactions: clinical and economic burden.
Curr Med Res Opin.
2006;
22
2007-2021
-
19
Alvarado C J, Reichelderfer M.
APIC guideline for infection prevention and control in flexible endoscopy. Association for Professionals in Infection Control.
Am J Infect Control.
2000;
28
138-155
-
20 Food and Drug Administration .Manufacturer and User Facility Device Experience Database (MAUDE). Food and Drug Administration, 2005 [accessed 2005, July 20]. http://www.fda.gov/cdrh/maude.html
-
21 Food and Drug Administration .Medical Device Reporting (MDR): General Information. Food and Drug Administration, 2002 [accessed 2005, July 20]. http://www.fda.gov/cdrh/mdr/mdr-general.html
-
22 Food and Drug Administration .FDA Enforcement Report Index 2005 [accessed 2005, July 20]. http://www.fda.gov/opacom/Enforce.html
-
23 Lautenbach E, Woeltje K (eds). Practical handbook for healthcare epidemiologists, 2nd edn. Thorofare, New Jersey; Slack Inc 2004
-
24
Manzoor S E, Lambert P A, Griffiths P A. et al .
Reduced glutaraldehyde susceptibility in Mycobacterium chelonae associated with altered cell wall polysaccharides.
J Antimicrob Chemother.
1999;
43
759-765
-
25
Archibald L, Phillips L, Monnet D. et al .
Antimicrobial resistance in isolates from inpatients and outpatients in the United States: increasing importance of the intensive care unit.
Clin Infect Dis.
1997;
24
211-215
-
26
Ward M M, Diekema D J, Yankey J W. et al .
Implementation of strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in U.S. hospitals.
Infect Control Hosp Epidemiol.
2005;
26
21-30
-
27
Goldmann D A, Weinstein R A, Wenzel R P. et al .
Strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in hospitals: a challenge to hospital leadership.
JAMA.
1996;
275
234-240
E. Seoane-Vazquez, PhD
College of Pharmacy
The Ohio State University
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Email: pharmacoeconomics@osu.edu
