Endoscopy 2007; 39(4): 369-370
DOI: 10.1055/s-2007-966098
Case report

© Georg Thieme Verlag KG Stuttgart · New York

Detection of tissue abnormalities in normal mucosa surrounding colorectal cancer using an endocytoscopy system

E.  Meroni1 , B.  Gatteschi2 , A.  Fasoli1 , F.  Munizzi1 , F.  Frascio1 , V.  Pugliese1 , M.  Truini2
  • 1Division of Endoscopy, National Institute for Cancer Research, Genoa, Italy
  • 2Division of Pathology, National Institute for Cancer Research, Genoa, Italy
Further Information

Publication History

submitted 19 September 2006

accepted after revision 10 November 2006

Publication Date:
11 April 2007 (online)

The endocytoscopy system is a novel diagnostic technique that provides extremely high-magnification imaging of the gastrointestinal mucosa. We are currently using a prototype Olympus endocytoscope for clinical research in gastrointestinal tumors. In one surgical specimen obtained after resection of a cancer of the transverse colon, focal abnormalities of colonic glands were detected 7 cm away from the primary tumor, within macroscopically normal mucosa. Our finding, which was confirmed by histopathological examination, suggests the need for further clinical investigation to assess whether endocytoscopy is able to identify premalignant changes in apparently normal mucosa. This could potentially be useful for accurate evaluation before planning minimally invasive therapy.

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E. Meroni, MD

Endoscopy Division

National Institute for Cancer Research

10 Largo Rosanna Benzi

16132 Genoa

Italy

Fax: +39-010-5600645

Email: emanuele.meroni@istge.it