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DOI: 10.1055/s-2007-957343
© Georg Thieme Verlag KG Stuttgart · New York
Circulating Serum Adiponectin Concentrations do not Differ between Obese and Non-obese Caucasians and are Unrelated to Insulin Sensitivity
Publication History
Received 2. 5. 2006
Accepted 14. 8. 2006
Publication Date:
16 January 2007 (online)
![](https://www.thieme-connect.de/media/hmr/200701/lookinside/thumbnails/10.1055-s-2007-957343-1.jpg)
Abstract
Reduced serum levels of adiponectin in obesity and insulin resistance seem paradoxical, since adipose tissue is the only source of adiponectin, and reports on that subject are contradictory. The aim of this study was to investigate the concentrations of adiponectin in non-obese and obese normoglycemic humans, and to determine the correlation between adiponectin and HOMA index of insulin sensitivity. Based on the WHO definition of obesity, 145 obese subjects and 49 non-obese controls (aged 20-55 years) were studied. The serum adiponectin concentrations did not differ between subjects and controls (p=0.6398) and were not correlated with HOMA index (r=-0.0211; p=0.8048, and r=-0.0523; p=0.4757, for subjects and controls, respectively). Adiponectin was not correlated with HOMA index in females (r=-0.0521; p=0.6546, and r=-0.0825; p=0.3981, for female subjects and controls, respectively) as well as in males (r=0.0033; p=0.9791, and r=0.0123; p=0.9131, for male subjects and controls, respectively). These results lead to the conclusion that neither the concentrations of adiponectin differ between obese and non-obese humans, nor does any relationship between adiponectin concentration and insulin sensitivity exist.
Key words
adipose - obesity - HOMA index - metabolism - diabetes
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Correspondence
M. Owecki
Department of Endocrinology
Metabolism and Internal Medicine
ul. Przybyszewskiego 49
60-355 Poznań
Poland
Phone: +4861869 13 30
Fax: +4861869 1682
Email: mowecki@amp.edu.pl