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Horm Metab Res 2007; 39(1): 25-30
DOI: 10.1055/s-2007-957343
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Circulating Serum Adiponectin Concentrations do not Differ between Obese and Non-obese Caucasians and are Unrelated to Insulin Sensitivity

M. Owecki 1 , A. Miczke 2 , D. Pupek-Musialik 2 , W. Bryl 2 , M. Cymerys 2 , E. Nikisch 3 , J. Sowiński 1
  • 1Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences in Poznań, Poland
  • 2Department of Internal Diseases, Metabolic Disturbances and Hypertension, University of Medical Sciences in Poznań Poland
  • 3Department of Informatics and Statistics, University of Medical Sciences in Poznań, Poland
Further Information

Publication History

Received 2. 5. 2006

Accepted 14. 8. 2006

Publication Date:
16 January 2007 (online)

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Abstract

Reduced serum levels of adiponectin in obesity and insulin resistance seem paradoxical, since adipose tissue is the only source of adiponectin, and reports on that subject are contradictory. The aim of this study was to investigate the concentrations of adiponectin in non-obese and obese normoglycemic humans, and to determine the correlation between adiponectin and HOMA index of insulin sensitivity. Based on the WHO definition of obesity, 145 obese subjects and 49 non-obese controls (aged 20-55 years) were studied. The serum adiponectin concentrations did not differ between subjects and controls (p=0.6398) and were not correlated with HOMA index (r=-0.0211; p=0.8048, and r=-0.0523; p=0.4757, for subjects and controls, respectively). Adiponectin was not correlated with HOMA index in females (r=-0.0521; p=0.6546, and r=-0.0825; p=0.3981, for female subjects and controls, respectively) as well as in males (r=0.0033; p=0.9791, and r=0.0123; p=0.9131, for male subjects and controls, respectively). These results lead to the conclusion that neither the concentrations of adiponectin differ between obese and non-obese humans, nor does any relationship between adiponectin concentration and insulin sensitivity exist.

Key words

adipose - obesity - HOMA index - metabolism - diabetes

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Correspondence

M. Owecki

Department of Endocrinology

Metabolism and Internal Medicine

ul. Przybyszewskiego 49

60-355 Poznań

Poland

Phone: +4861869 13 30

Fax: +4861869 1682

Email: mowecki@amp.edu.pl