Synlett 2008(10): 1510-1514  
DOI: 10.1055/s-2007-1077795
LETTER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 8-Heteroaryl-2′-deoxyguanosine Derivatives

Gerard Hobley, Vladimir Gubala, María Del C. Rivera-Sánchez, José M. Rivera*
Department of Chemistry, College of Natural Sciences, University of Puerto Rico, Río Piedras Campus, San Juan 00931, Puerto Rico
Fax: +1(787)7568242; e-Mail: jmrivortz@mac.com;
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Publikationsverlauf

Received 14 December 2007
Publikationsdatum:
19. Mai 2008 (online)

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Abstract

We describe the synthesis of 8-heteroaromatic-2′-de­oxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2′-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.

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