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Int J Sports Med 1990; 11: S15-S20
DOI: 10.1055/s-2007-1024848
© Georg Thieme Verlag Stuttgart · New York

IV. Oxygen Transport System Before and After Exposure to Chronic Hypoxia

G. Ferretti1 , U. Boutellier1 , D. R. Pendergast2 , C. Moia1 , A. E. Minetti1 , H. Howald3 , P. E. di Prampero1 , 4
  • 1Department of Physiology, University of Geneva Medical School, Geneva, Switzerland
  • 2Department of Physiology, State University of New York at Buffalo, Buffalo, NY, USA
  • 3Research Institute of the Swiss School of Physical Education and Sports, Magglingen, Switzerland
  • 4Institute of Biology, University of Udine, Udine, Italy
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Publication Date:
14 March 2008 (online)

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Abstract

Maximal V̇O2 on the treadmill (V̇O2max) and on the bicycle ergometer (V̇O2peak), maximal cardiac output (Qmax), by a CO2 rebreathing method, maximal heart rate (HRmax), blood hemoglobin concentration (Hb), and hematocrit (Hct) were measured on six subjects before (B) and 3 weeks after (A) prolonged exposure to chronic hypoxia. It was observed that after high-altitude exposure V̇O2max, V̇O2peak, and Qmax were lower (P < 005) than before [A: 4.13 ± 0.67; 3.28 ± 0.41 and 16.89 ± 2.49 (1/min ± SD); B: 4.39 ± 0.39; 3.53 ± 0.34 and 21.81 ± 1.27, respectively], whereas Hb and Hct were larger (A: 162 ± 8 g/1 and 0.46 ± 0.02; B: 142 ± 7 and 0.41 ± 0.02) and HRmax was unchanged (178 ± 7 vs 175 ± 9 bts/min). Thus, the calculated stroke volume of the heart and the Hb flow at V̇O2 peak were lower in A than in B(95 ± 15 vs 124 ± 7 ml and 2,723 ± 307 vs 3,129 ± 196 g/min) (P < 0.05, respectively), whereas the arteriovenous O2 difference was greater in A than in B (195 ± 16 vs 162 ± 19 ml O2/1; p < 0.05). At any given submaximal work load, V̇O2 and HR were the same in B and in A, whereas Q was lower in A by ∼ 2-3 1/min. However, because of the increased Hb, leading to a higher arterial O2 content, at any work load the O2 flow remained unchanged.

Key words

maximum O2 consumption - cardiac output - limiting factors - hemoglobin - blood O2 concentration