Effect of Training and Detraining on In Vivo Insulin Sensitivity

Abstract

Insulin sensitivity was determined in rats to clarify the effect of detraining at 1 (trained state), 2, 3, and 7 days (7 rats each) and 14 days (n = 8) after five weeks of voluntary training using euglycemic insulin clamp technique. The relationship between basal insulin and glucose shifted towards a decrease in metabolic insulin needs compared to untrained controls (n = 20). During the insulin clamp study, to maintain comparable plasma glucose and insulin levels in all groups, the glucose infusion rate had to be increased significantly (p < 0.01) to 9.92 ± 1.12 mg·kg^-1 · min^-1 compared to control group (6.57 ± 0.57). This improved sensitivity persisted for 2 days after training but was significantly lowered in the 7-days-after group (p < 0.01). In summary, this study shows that training effect on insulin sensitivity can be determined after voluntary training in rat. This training effect lasted 2 days after training.

Key words

Insulin sensitivity - training - detraining - rat - glucose metabolism - insulin clamp technique