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DOI: 10.1055/s-2007-1023343
Fever, Leucocytosis and Infection after Open Heart Surgery. A Log-linear Regression Analysis of 115 Cases
Publication History
1983
Publication Date:
19 March 2008 (online)
![](https://www.thieme-connect.de/media/thoracic/198401/lookinside/thumbnails/10.1055-s-2007-1023343-1.jpg)
Summary
A prospective investigation was undertaken in adults to assess the specificity and sensitivity of fever (≥ 38 °C) and leucocytosis (≥ 10 000/μI) the diagnosis of infection after operations with cardiopulmonary bypass. A log-linear model analysis of a multiway frequency table was used for statistical evaluation. The model parameters were separately evaluated for 2 periods: the early one until the 6th day, the late period from the 7th postoperative day until discharge. Seven out of 115 patients suffered infections during their hospital stay: Bacteremia occurred in 3, pneumonia in 2, and deep sternal wound infection in 2 patients, and a superficial wound infection in one. No significant interactions between fever, leucocytosis and/or infection were found in the first period, except an inverse relation between fever and elevated WBC (p - 0.0197). After the 6th postoperative day the model parameters did show significant interactions, fever and leucocytosis being more frequent in infected patients. However, the specificity was low: only 15% of the patients with fever or elevated WBC had an infection. The risk of in hospital infection was significantly higher after a long duration of cardiopulmonary bypass (p = 0.009), and after transfusion of more than 2500 ml of blood on the day of operation (p = 0.001).
Key words
Extracorporeal circulation - Fever - Leucocytosis - Postoperative infection - Log-linear model