Download PDF
Thorac Cardiovasc Surg 1986; 34(3): 163-167
DOI: 10.1055/s-2007-1020401
© Georg Thieme Verlag Stuttgart · New York

A Qualitative Analysis of Pulsatile Perfusion: Effects on Cortisol Response to Cardiopulmonary Bypass Surgery

M. Azariades, A. J. Wood, Y. Awang, S. C. Lennox
  • Department of Cardiothoracic Surgery, Brompton Hospital, London, England
Further Information

Publication History

1985

Publication Date:
09 May 2008 (online)

  PDF Download  Permissions and Reprints All articles of this category

Summary

Continuous analysis of pressure waveform has enabled quantitative assessment of pulsatile perfusion in a series of 51 patients randomly allocated to “pulsatile” (N = 37) and “non-pulsatile” (N = 14) groups. Cortisol and hematocrit (PCV) were measured preoperatively, at 2 minutes and 30 minutes after the start of bypass and just prior to the end of bypass. Radial artery pressure, pulse pressure and dp/dt were recorded continuously on a specially constructed device.

Though there was significant difference between the pulsatile and non-pulsatile groups in terms of pulse pressure (P < 0.001) and dp/dt (P<0.01), no difference was demonstrated in terms of mean arterial pressure (P>0.4), total plasma cortisol (P>0.9) and PCV corrected plasma cortisol (P>0.8). Multiple regression analysis of cortisol and change in cortisol with pulse pressure dp/dt and mean arterial pressure failed to show any correlation.

We found a normal cortisol response to surgery irrespective of the quality of pulsation.

Key words

Pulsatile - Non-pulsatile - Flow - Cortisol