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Horm Metab Res 1981; 13(6): 340-342
DOI: 10.1055/s-2007-1019261
© Georg Thieme Verlag, Stuttgart · New York

In Vivo Effect of 13 Leu Motilin on the Electric Activity of the Rabbit Sphincter of Oddi

J. C. Sarles, P. Delecourt, M. A. Devaux, J. P. Amoros, J. C. Guicheney, E. Wünsch
  • Service de Chirurgie, C.H.U. Nord, and Unité de Recherches de Pathologie Digestive, U 31 INSERM, Marseilles, France
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Publication History

1979

1980

Publication Date:
14 March 2008 (online)

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Summary

Myoelectrical activity of the sphincter of Oddi was studied in 15 anaesthetized and laparotomized male rabbits, before and after injection of various doses of 13 Leucine Motilin (13 L Motilin), a biological and structural analogue of natural motilin. It can be concluded that 13 L Motilin provoked an increase of the sphincter of Oddi spike activity with doses ranging from 0.1 to 1.6 × 10-6 g/kg. This effect had begun one minute after the injection, reached its maximum at the second minute and lasted for fifteen minutes. The action of 13 L Motilin is dose-related between 0.2 and 0.6 × 10-6.

Key-Words:

Motilin - Sphincter of Oddi - Electromyography - Rabbit