Horm Metab Res 1981; 13(4): 224-228
DOI: 10.1055/s-2007-1019227
© Georg Thieme Verlag, Stuttgart · New York

Effects of Glucocorticoids on Hormone-Stimulated Lipolysis and Calcium Uptake in the Adipose Cells

A. Kawai, N. Kuzuya
  • Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
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Publikationsverlauf

1980

1980

Publikationsdatum:
23. April 2008 (online)

Summary

Hormone-induced lipolysis and calcium accumulation were concomitantly reduced in the adipose tissue from adrenalectomized rats. In contrast, both epinephrine-activated lipolysis and calcium accumulation were potentiated when the adipocytes were preincubated with 33 ng/ml of dexamethasone for 3 hrs.

These potentiating effects of dexamethasone on epinephrine-stimulated lipolysis were completely inhibited when the adipocytes were preincubated with the steroid and verapamil which inhibited hormone-induced calcium influx into the adipocytes. These findings suggest that the potentiating effect of glucocorticoid on hormone-stimulated lipolysis depends upon its accerelating action on hormone-induced calcium influx into the adipocytes.