Horm Metab Res 1981; 13(3): 155-157
DOI: 10.1055/s-2007-1019204
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

The Effect of Unilateral Nephrectomy and Sham Operation on Tyrosine Content and Activity of Tyrosine Aminotransferase in the Rat

Teresa Laskowska-Klita, Malgorzata Bong
  • Department of Biochemistry, Institute of Biopharmacy, Warsaw Medical School, Warsaw, Poland
Further Information

Publication History

1979

1980

Publication Date:
14 March 2008 (online)

Summary

During the first four days after unilateral nephrectomy the free tyrosine content in plasma, liver and hypertrophic kidney was decreased by more than 50% as compared with the values observed in intact rat. After sham operation, the content of tyrosine was decreased to the same extent.

The activity of tyrosine aminotransferase in liver was doubled two days after sham operation: no such increase was observed after unilateral nephrectomy. At the same time a decline of the enzyme activity in kidney was demonstrated after both types of surgery.

Hydrocortisone in a single i.p. dose stimulated enzyme activity in the liver of intact rats three-fold, and more than fourfold after nephrectomy and sham operation. In kidney of intact rat, as a result of hydrocortisone treatment, the enzyme activity was doubled; it was, however, insensitive to this treatment after unilateral nephrectomy, and increased only by 20 % after sham operation.

It is suggested that the changes in tyrosine content and tyrosine aminotransferase activity observed after unilateral nephrectomy were not due to stress alone, but underwent regulation aimed at assuring a sufficient level of this amino acid for metabolism.