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Semin Reprod Med 1999; 17(3): 267-274
DOI: 10.1055/s-2007-1016234
Copyright © 1999 by Thieme Medical Publishers, Inc.

Embryonic Regulation in Implantation

Carlos Simón, Julio Cesar Martín, Arancha Galan, Diana Valbuena, Antonio Pellicer
  • Department of Pediatrics, Obstetrics and Gynecology, Instituto Valenciano de Infertilidad Foundation (FIVIER), Valencia University, Valencia, Spain.
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Publication History

Publication Date:
15 March 2008 (online)

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Abstract

Maternal steroid hormones play a critical role in establishing the receptive phase of implantation. In addition to that, the embryo is able to modulate endometrial molecules during the apposition phase (chemokines) and the adhesion phase (adhesion and anti-adhesion molecules). Moreover, the human embryo also exerts a coordinated regulation of endometrial epithelial apoptosis during these implantation phases. In this work, we analyze the embryonic regulation of implantation in humans using an in vitro model.

Keywords:

Endometrium - embryo - implantation - adhesion - apoptosis