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Horm Metab Res 1984; 16(6): 315-318
DOI: 10.1055/s-2007-1014777
© Georg Thieme Verlag, Stuttgart · New York

The Influence of Plasma Renin Substrate on the Relationship between Plasma Renin Activity and Plasma Renin Concentration

An Experimental Study in Hyper- and Hypothyroid RatsE. Jiménez, M. Montiel, J. A. Narváez, M. T. Miranda1 , L. Parras1 , M. Morell
  • Departamento de Fisiología y Bioquímica, Facultad de Medicina, Universidad de Málaga, Máelaga, Spain
  • 1Departamento de Bioestadística, Facultad de Medicina, Universidad de Málaga, Máelaga, Spain
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Publication History

1982

1983

Publication Date:
14 March 2008 (online)

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Summary

The effects of endogenous Plasma Renin Substrate (PRS) on the relationship between Plasma Renin Activity (PRA) and the Plasma Renin Concentration (PRC) have been studied in hyperthyroid rats, by I-triiodothyronine (T3) administration and in hypothyroid rats, by propylthiouracil (PTU) treatment, to clarify if PRA changes are an adequate index for evaluating the renin-angiotensin changes during the alterations in the thyroid function.

Although in experimental situations studied the induced variation on PRC explains a 62 per cent of the changes in PRA, finding a good lineal correlation between both parameters (r = 0.79, P < 0.001). Not only does PRS play an important role on the kinetic of the enzymatic reaction but also explains jointly with PRC up to a 85 per cent of PRA alterations. PRS changes become more important during thyrotoxicosis where they limit in a higher degree the velocity of reaction due to inverse relationship between PRC and PRS (r = 0.74, P < 0.001).

Key-Words:

Plasma Renin Concentration - Plasma Renin Activity - Plasma Renin Substrate - Thyroid Hormones