Metabolic and Hormonal Parameters after Insulin- Induced Hypoglycemia in Man, Comparison between Biosynthetic Human Insulin and Purified Pork Insulin

Summary

Although clinically undistinguishable, some authors have found important differences in the counterregulatory response between Biosynthetic Human Insulin (BHI) and Purified Pork Insulin (PPI).

To reassess the problem 10 healthy volunteers of both sexes underwent paired iv insulin tolerance test with both BHI and PPI (0.10 U/kg b.w.). To check the humoral response the variations of glucose, free fatty acids (FFA), prolactin, growth hormone, ACTH and plasma ren in activity were evaluated.

Blood glucose depression and further recovery by BHI and PPI administration paralleled each other, so were, prolactin, FFA, and plasma renin activity. A slight secretion of ACTH, and GH was observed under BHI challenge. There were not statistically significant differences between both insulins on any of the six parameters studied.

The data do not confirm earlier published reports indicating hormonal and metabolic differences between human and porcine insulin.

Key-Words:

Growth Hormone - Prolactin - FFA - ACTH - Renin - Hypoglycemia - Biosynthetic Human Insulin - Purified Pork Insulin - Recombinant DNA