Effect of βh-Endorphin on Release of Insulin by Rabbit Pancreas in Response to Four Secretagogues: Comparison with Somatostatin and Epinephrine

D. Rudman; M. H. Kutner

doi:10.1055/s-2007-1012318

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Horm Metab Res 1986; 18(6): 365-368
DOI: 10.1055/s-2007-1012318

ORIGINALS

Effect of β_h-Endorphin on Release of Insulin by Rabbit Pancreas in Response to Four Secretagogues: Comparison with Somatostatin and Epinephrine

D. Rudman, M. H. Kutner

Department of Medicine, University of Health Sciences, The Chicago Medical School, North Chicago, Illinois, and Department of Biometry, Emory University School of Medicine, Atlanta, Georgia, U.S.A.

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Publication History

1984

1985

Publication Date:
14 March 2008 (online)

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Summary

Previous work showed β_h-endorphin inhibits glucose-stimulated secretion of insulin by rabbit pancreas slices. This study, also conducted with rabbit pancreas slices, compared the antisecretagogue actions of β_h-endorphin, somatostatin _1-14, and epinephrine versus four secretagogues, glucose, mannose, leucine and potassium chloride. All three antisecretagogues inhibited all four secretagogues. The order of potency of the antisecretagogues varied according to secretagogue. Naloxone antiagonized only β_h-endorphin among the three antisecretagogues, and phentolamine antagonized only epinephrine.

Key-Words

β_h-Endorphin - Insulin Release - Rabbit Pancreas