Eight Weeks of Streptozotocin-Induced Diabetes Influences the Effects of Cold Stress on Immunoreactive Beta-Endorphin Levels in Female Rats

L. J. Forman; S. Estilow; J. Mead; P. Vasilenko

doi:10.1055/s-2007-1010883

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Horm Metab Res 1988; 20(9): 555-558
DOI: 10.1055/s-2007-1010883

ORIGINALS

Eight Weeks of Streptozotocin-Induced Diabetes Influences the Effects of Cold Stress on Immunoreactive Beta-Endorphin Levels in Female Rats

L. J. Forman¹ , S. Estilow¹ , J. Mead² , P. Vasilenko²

¹Department of Medicine, University of Medicine and Dentistry of New Jersey - School of Osteopathic Medicine, Camden, New Jersey, U.S.A.
²Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey - School of Osteopathic Medicine, Camden, New Jersey, U.S.A.

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Publication History

1987

1987

Publication Date:
14 March 2008 (online)

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Summary

Cold stress produced a significant reduction in the concentration of immunoreactive beta-endorphin (IR-BE) in the anterior pituitary of diabetic female rats. IR-BE levels in the anterior pituitary of non-diabetic female rats were not affected by exposure to the cold. The effects of cold stress on IR-BE levels in the neurointermediate lobe of the pituitary and the hypothalamus were attenuated in diabetic as compared to control animals. These data suggest that in female rats, eight weeks of diabetes produced alterations in the neuroendocrine mechanisms which modulate IR-BE levels in the pituitary and hypothalamus in response to cold stress.

Key-Words

Diabetes - Stress - Beta-Endorphin - Female Rats