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Horm Metab Res 1988; 20(1): 24-27
DOI: 10.1055/s-2007-1010740
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© Georg Thieme Verlag, Stuttgart · New York

The Effects of Gastric Inhibitory Polypeptide and Insulin on Fatty Acid Uptake in Adipose Tissue are not Mediated Through Cyclic AMP in Lean and Obese Zucker Rats

B. Beck, J. P. Max
  • INSERM U.59, Unité de Nutrition et Diététique, Nancy and Université de Nancy I, Nancy, France
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Publication History

1986

1987

Publication Date:
14 March 2008 (online)

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Summary

To determine the mechanism by which gastric inhibitory polypeptide (GIP) and insulin stimulate the in vitro fatty acid incorporation into adipose tissue (FIAT), me measured the cyclic AMP variations and FIAT in epididymal fat pads of lean Fa/- and obese fa/fa Zucker rats. GIP was used at 1, 2 and 4 ng/ml and insulin at a concentration of 100 μU/ml. There was no significant variation of cAMP when FIAT was stimulated either by GIP, either by insulin or by both hormones. There was no correlation at all between FIAT increases and cAMP levels. We conclude that GIP and insulin act through cAMP independent mechanisms in adipose tissue. The modification by GIP of insulin binding to adipocytes or an easier passage of fatty acids through the membrane could constitute alternative solutions for such mechanisms.

Key-Words

Insulin - Gastric Inhibitory Polypeptide - Adipose Tissue - Fatty Acid Incorporation - Cyclic AMP - Rat

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